of National Academy of Sciences
of Tajikistan

News of the National Academy of Sciences of Tajikistan.
Department of physical, mathematical, chemical, geological and technical sciences

Известия Академии наук Республики Таджикистан. Отделение физико-математических, химических, геологических и технических наук, №2, 2014 г.

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Khalikov D.Kh., Rakhimov I.F., Khaydarov K.Kh., Mirsaidov U.M.
Topical issues of chemistry and pharmacology
Scientific researches in chemistry and pharmacology conducted in V.I. Nikitin Institute of Chemistry are systematized in present work. Ways of practical using of synthesized matters in pharmacology are shown.

Ключевые слова: карбатин; облепиховое масло; сорбент; полимер; бентонит; хлорид натрия; karbatin; sea buckthorn oil; sorbent; polymer; bentonite; sodium chloride.

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Ruzmatova G.K., Kadirov M.Z., Hakimova D.K., Islomova M.S., Abrorkhonov A.
Calorimetric definition of the enthalpy of formation of hydrofluorides of the IA elements of the subgroup
The method of a calorimetry of dissolution determined an enthalpy of reaction of interaction of carbonates of the IA elements of a subgroup (Li, by Na, K). Possibility of formation of hydrofluorides of different structures depending on concentration of fluoric acid is established. Enthalpies of formation of hydrofluorides of the IA elements of a subgroup are defined.

Ключевые слова: карбонаты; плавиковая кислота; элементы IA подгруппы; гидрофториды; калориметрия; энтальпия образования; термодинамическая стабильность; carbonates; fluoric acid; subgroup IA elements; hydrofluorides; calorimetry; education enthalpy; thermodynamic stability.

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Badalov A., Gafurov B.A., Mirsaidov U.M.
Borohydrides of rare earth metals with tetrad-effect: appearance at defined thermodynamic characteristics
The appearance of tetrad-effect on the graphic chart of thermodynamic characteristics of borohydrides of lanthanides on atomic number of lanthanide is defined by means of tensimetric method with membrane zero-manometer with X-ray phase, chemical and gas volumetric analysis.

Ключевые слова: редкоземельные металлы; борогидриды; тетрад-эффект; термодинамические характеристики; rare earth metals; borohydrides; tetrad-effect; thermodynamic characteristics.

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Faizilov I.U., Isobaev M.J., Pulatov E.H., Haidarov K.H.
Synthesis of the tri-tretic enin triols containing isolated double bond
By the way of condensation of enin alcohol with the oxyketones, at the Favorsky reaction conditions the tritretic enin triols containing isolated double bond has been preparated.

Ключевые слова: ениновый спирт; оксикетоны; реакция Фаворского; тритретичные ениновые триолы; изолированная кратная связь; enin alkagoles; oxikethones; Favorsky reaction; tri-tretic enin triols; isolated double bond.

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Khojibaev Y., Mamadshoeva S.S., Rakhmonov R.O., Kukaniev M.A., Crucianelli M., Pietropaolo E.
Synthesis and properties of amino derivatives 2-methylthio-7-chloromethylen-5-oxo-5Н-1,3,4-thiadiazolo-[3,2-a]-pyrimidine
The results of studies on the synthesis of 2-methylthio-7-chlormethylen-5-oxo-5H-1,3,4-thiadiazolo-[3-2-a]- pyrimidine by cyclization 2-methylthio-5-amino 1,3,4-thiadiazole with с 4-chloroethylacetoacetate. Reaction of nucleophilic substitution of chlorine 2-methylthio-7-chlormethylen-5-oxo-5H-1, 3, 4-thiadiazolo-[3-2-a] - pyrimidine on amines. Structure of 2-methyl-7-chlormethylen-5-oxo-5H-1,3,4-thiadiazolo-[3-2-a]- pyrimidine and 2- methylene- amine- 7-chlormethylen-5-oxo-5H-1,3,4-thiadiazolo-[3-2-a]- pyrimidine was checked by IR, H-and C-spectroscopic analyzes.

Ключевые слова: 2-метилтио-5-амино-1,3,4-тиадиазол-4-хлороацетоуксусный эфир; 2-метилтио-7-хлорметилен-5-оксо-5Н-1,3,4-тиадиазоло-[3,2-a]-пиримидин; 2-метилтио-7-метиленамин-5-оксо-5Н-1,3,4-тиадиазоло-[3,2-a]-пиримидин; валентные колебания; 2-methylthio-5-amino-1,3,4-thiadiazole-4-chlorоacetoacetate ether; 2-methyl-7-chlormethylen-5-oxo-5H-1,3,4-thiadiazolo-[3,2-a]-pyrimidine; 2-methylene amine-7-chlormethylen-5-oxo-5H-1,3,4-thiadiazolo-[3,2-a]-pyrimidine; stretching vibrations.

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Rakhmonov R.O., Khojibaev Y., Zoidova M.T.
Synthses and nmr-spectral characteristic of 2-substituated the derivatives of 2-p-bromphenylimidazo-[2,1-b]-1,3,4-thiadiazole
In this paper was present the synteses of new condensened derivatives of thiadiazole in basis of the nuclephilic substitueted reaction of 2-р-bromphenylimidzo-[2,1-b]-1,3,4-thiadialole with amine. Composition and structure of obtained compounds were determined with Н-, С- NMR , IR-spectura and element analysis.

Ключевые слова: 2-бром-6-п-бромфенилимидазо-[2,1-b]-1,3,4-тиадиазол; нуклеофильное замещение; этиламин; диметиламин; диэтиламин; морфолин - 2-этиламин-6-п-бромфенилимидазо-[2,1-b]-1,3,4-тиадиазол; 2-диметиламин-6-п-бромфенилимидазо-[2,1-b]-1,3,4-тиадиазол; 2-морфолин-6-п-бромфенилимидазо-[2,1-b]-1,3,4-тиадиазол; химический сдвиг; нуклеофильные агенты; 2-bromo-6-p-bromphenylimidzo-[2,1-b]-1,3,4-thiadialole; nucleоphilic substitution; ethylamine; dimethylamine; diethylamine; morpholene; 2-ethylamino-6-р-bromphenylimidzo-[2,1-b]-1,3,4-thiadialole; 2-dimethylamino-6-р-bromphenylimidzo-[2,1-b]-1,3,4-thiadialole; 2-morpholeno-6-р-brom-phenylimidzo-[2,1-b]-1,3,4-thiadialole; chemical shift; nucleоphile.

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Tashbaev G.A., Turdialiev M.Z., Tuhtasunov O.
Sinthesis of the n,n-(dialkyl)aminometilbenzo-1,4-dioxanes
The new substituted of the aminometils were synthesized from the benzo-1,4-dioxan and urea.

Ключевые слова: амины; бензо-1,4-диоксан; аминометилирование; аmines; benzo-1,4-dioxan; aminometils.

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Haydarov K.H., Usmanov R., Usmanov U.R., Mullochaeva M.D., Saidova Sh.I.
The information on the synthesis of β-aminoketones semiaromatic sulfur compounds by reacting hydrochlorides of secondary amines by acyl derivatives of 2,3-dihydrobenzo[b]thiophene and 1-thiochromanyl with formaldehyde in ethyl alcohol. The dependence of the anesthetic activity of the synthesized compounds on their structure.

Ключевые слова: синтез; аминометилирование; физико-химические характеристики; элементный анализ; полоса поглощения; анестезирующие свойства; synthesis; aminomethylation; рhysical сharacteristics; elemental analysis; absorption band; anesthetic properties.

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Badalov A., Mahmudov F.M., Badalova M.A., Abdusalyamova M.N., Jalilov R.A.
Thermic characteristics of intermetallic systems antimony-lanthanides and antimony-manganese-lanthanaides
The melting temperatures of intermetallic systems antimony-lanthanides and antimony-manganese-lanthanides were specified and determined by semiempirical method. The regularity of changing characteristics of the given intermetallic compounds’ depending on the lanthanides nature were also determined.

Ключевые слова: интерметаллиды; температура плавления; сурьма; лантаноиды; марганец; закономерность; intermetallic compounds; melting temperature; antimony; lanthanides; manganese; regularity.

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Khaidarov K., Rakhimov I.F., Abdusalyamova M.N., Sadirov A., Souhail R. AL-Abed
Morphofunctional changes of organ tissues and immunity system under interaction with nanostructured erbium oxide (Er O )
The influence nanostructure oxide erbium on the immune system and of some animals tissues were carried out. The orallyadministered no acute toxicity, no effect on the immune system of the body, has no effect on blood cells have beenknown. But long-term (30 day) intragastric administration shows toxicities on the internal organs of experimental animals, which lead to structural changes and functional impairment due to tissue accumulation of nanoparticles. There are two thesis were written and sent to International Symposium and an article for publication in a scientific journal during the working period.

Ключевые слова: наноструктурированный оксид; токсичность; иммунная система; nanostructured oxide; toxicity; the immune system.

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Goibova Z.V., Bobokalonova M.R., Rahimov I.F., Muhidinov Z.K., Razikova G.V., Saidov A.A.
Toxicity study of the emulsion microcapsules of apple pectin and whey lactoglobulines
Toxicity study of the emulsion microcapsules fabricated from whey lactoglobulins and apple pectin is described. After perioral feeding of experimental animals even by maximal dose any toxicity effect didn’t observed. From experimental results it was impossible to determine lethal dose of studied objects, which indicate that emulsion microcapsules can be ranked as nontoxic material.

Ключевые слова: лактоглобулины; яблочный пектин; эмульсия; токсичность; apple pectin; lactoglobulins; emulsion; toxicity.

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Ishankulova B.A.
Comparative pharmacology of some antidiabetic plants of tajikistan
The author’s research and experimental study of the most promising medicinal plants has revealed a pronounced hypoglycemic effect of the local flora. The reliable experimental data allow the authors to recommend the decoctions and extracts of Radix Geranium collinum , Fructus Sophorae japonicae , and infusion of Vitis vinifera for the complex treatment of patients with diabetes mellitus type II of mild to moderate severity.

Ключевые слова: лекарственные растения; сахарный диабет; риментальные исследования; medicinal plants; diabetes mellitus; experimental investigations.

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Odilov B.Kh., Djobirova T.M., Bobiev G.M., Rakhimov I.F.
The influence of thymizin to indices of blood of patients at complex treatment of chronic prostatitis
There are the dates about influence of immunomodulating preparation thymozin to indices of blood of patients at treatment of chronic prostatitis. It is shown that inclusion of thymozin to complex treatment of disease is promoting of greater degree of normalization of content of hemoglobin, amount of leukocytes, erythrocytes and rate of precipitation of erythrocytes in comparison with traditional therapy.

Ключевые слова: тимоцин; простатит; терапия; нормализация; показатели крови; thymozin; prostatitis; therapy; normalization; indices of blood.

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Davlatmamadova M.M., Ruziev J.R., Jamshedov J.N., Isupov S.J.
Aydrochloric way of purification of talc Mulvoj deposit
The article contains research outcomes onworking out technology of purification of talc in Mulvoj deposit, Ishkashim district of GBAO, Republic of Tajikistan, througt hydrochloric decomposition. Optimal parametres of applying technological processes of asid decomposition are discovered.

Ключевые слова: тальк; соляная кислота; фармация; talk; acid hydrochloric; pharmaceutical.

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